Interactions between ingrowing nerve fibers and their target tissues form the basis for
functional connectivity with the central nervous system. Studies of the developing dental …

The purpose of this review is to discuss molecular factors influencing nerve growth to teeth.
The establishment of a sensory pulpal innervation occurs concurrently with tooth …

Like many other organs, the tooth develops as a result of the epithelial‐mesenchymal
interactions. In addition, the tooth is a well‐defined peripheral target organ for sensory …

The neuropeptide substance P (SP) is found within a subpopulation of nociceptive afferent
nerve fibres and has been shown to be upregulated in a variety of sites following peripheral …

During development, trigeminal nerve fibers navigate and establish their axonal projections
to the developing tooth in a highly spatiotemporally controlled manner. By analyzing …

Target-derived neurotrophins support and sustain peripheral sensory neurons during
development. In addition, it has been suggested that these growth factors could have …

The erupted tusk of the narwhal exhibits sensory ability. The hypothesized sensory pathway
begins with ocean water entering through cementum channels to a network of patent …

The dental pulp consists of loose connective tissue encased in rigid dentinal walls. Because
of its topography the tissue has low interstitial compliance and limited capacity to expand …

The potential for osteogenic differentiation of dental pulp mesenchymal stem cells
(DPMSCs) in vitro and in vivo has been well documented in a variety of studies. Previously …

To analyze the roles of neurotrophins during early development of rat teeth, we studied the
expression of neurotrophin mRNAs from the initiation of first molar formation to the …