Background Rotator cuff disease is a widespread musculoskeletal pathology and a major
cause of shoulder pain. Studies on familial predisposition suggest that genetic plays a role …

Sports genomics is the scientific discipline that focuses on the organization and function of
the genome in elite athletes, and aims to develop molecular methods for talent identification …

There is mounting evidence suggesting a genetic contribution to the susceptibility of
sustaining a musculoskeletal soft-tissue injury. To date, more than 70 loci have been …

Evidence for a heritable predisposition to rotator cuff tears (RCTs) is growing. Unrelated
Caucasian individuals with surgically diagnosed full thickness RCTs (cases) and elderly …

Background Studies suggest that the collagen degeneration and disordered arrangement of
collagen fibers in rotator cuff tears are associated with an increase in activity of matrix …

Background: Tibialis posterior tendon dysfunction is a common disorder leading to pain,
deformity, and disability, although its pathogenesis is unclear. A vascular etiology has been …

Abstract Background Tendon-ligament injuries (TLIs), including Achilles tendinopathy,
cruciate ligament injury, tennis elbow, rotator cuff injury, patellar tendinopathy, and tibial …

Osteoarthritis is the most common form of arthritis with still unknown pathogenic etiology and
considerable contribution of genetic factors. One of the mechanisms of cartilage degradation …

Progressive collapsing foot deformity (PCFD) is one of the most controversial topics in foot
and ankle surgery. Reviews normally focus on different surgical approaches depending on …

To date, more than 18 genomic intervals, which underpin the complex myriad of extracellular
matrix interactions of tendons, have been implicated in risk models for tendinopathy. It is …