Drug repositioning is an important component of therapeutic stratification in the precision
medicine paradigm. Molecular profiling and more sophisticated analysis of longitudinal …

What is known and objective In order to expedite the availability of drugs to treat cancers in a
cost‐effective manner, repurposing of old drugs for oncological indications is gathering …

Drug discovery and development are long and financially taxing processes. On an average
it takes 12–15 years and costs 1.2 billion USD for successful drug discovery and approval …

An increasing resistance of mammalian tumor cells to chemotherapy along with the severe
side effects of commonly used cytostatics has raised the urgency in the search for new anti …

Ovarian cancer is the most lethal gynecologic malignancy with an overall cure rate of merely
30%. Most patients experience recurrence within 12–24 months of cure and die of …

Abstract Background/Aims Colorectal cancer is the third leading cause of death in patients
with cancers in America. Monensin has represented anti-cancer effect on various human …

Discovery of first-in-class medicines for treating cancer is limited by concerns with their
toxicity and safety profiles, while repurposing known drugs for new anticancer indications …

Asthma is a chronic disease that is caused by airway inflammation. The main features of
asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The …

Background/Aims: Ovarian cancer is the most lethal gynecologic malignancy, and there is
an unmet clinical need to develop new therapies. Although showing promising anticancer …

Background/Aims: As the most lethal urological cancers, renal cell carcinoma (RCC)
comprises a heterogeneous group of cancer with diverse genetic and molecular alterations …