The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200
nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel …

Biomolecular condensates organize biochemical processes at the subcellular level and can
provide spatiotemporal regulation within a cell. Among these, ribonucleoprotein (RNP) …

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides but lacking
canonical coding sequences. Apparently unable to produce peptides, lncRNA function …

Small open reading frames (smORFs) of 100 codons or fewer are usually—if arbitrarily—
excluded from proteome annotations. Despite this, the genomes of many metazoans …

Short open reading frames (sORFs) are a common feature of all genomes, but their coding
potential has mostly been disregarded, partly because of the difficulty in determining …

Technological advances over the past decade have unraveled the remarkable complexity of
RNA. The identification of small peptides encoded by long non-coding RNAs (lncRNAs) as …

Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters
by specific DNA-binding transcription factors is well recognized as a key regulatory step in …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Thousands of small Open Reading Frames (smORFs) with the potential to encode small
peptides of fewer than 100 amino acids exist in our genomes. However, the number of …