Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …

Mutants of translation components which compensate for both− 1 and+ 1 frameshift
mutations showed the first evidence for framing malleability. Those compensatory mutants …

Nearly half of the ribosomes translating a particular bacteriophage T4 mRNA bypass a
region of 50 nt, resuming translation 3′ of this gap. How this large-scale, specific hop …

The ribosome can slide along mRNA without establishing codon-anticodon interactions.
This movement can be regulated (programmed) by the elements encoded in the mRNA, as …

In Streptomyces species, the cell cycle involves a switch from an early and vegetative state
to a later phase where secondary products including antibiotics are synthesized, aerial …

Programmed translational frameshifting is a ubiquitous but rare mechanism of gene
expression in which mRNA sequences cause the translational machinery to shift reading …

Background A remarkable sequence in phage T4 causes ribosomes to skip over a 50
nucleotide insert within a topoisomerase subunit gene, and resume correct synthesis of the …

Efficient translational bypassing of a 50-nt non-coding gap in a phage T4 topoisomerase
subunit gene (gp60) requires several recoding signals. Here we investigate the function of …

Ribosomal bypassing can lead to the translational fusion of non-contiguous ORFs. It
involves dissociation of codon: anticodon pairing in the ribosomal P-site followed by mRNA …

The tri-frame model gives mathematical expression to the transcription and translation
processes, and considers all three reading frames (RFs). RNA polymerases transcribe DNA …