The contribution of environmental exposure to the etiology of autism spectrum disorder

S Bölte, S Girdler, PB Marschik - Cellular and Molecular Life Sciences, 2019 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental condition of heterogeneous
etiology. While it is widely recognized that genetic and environmental factors and their …

The changing epidemiology of autism spectrum disorders

K Lyall, L Croen, J Daniels, MD Fallin… - Annual review of …, 2017 - annualreviews.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with lifelong
impacts. Genetic and environmental factors contribute to ASD etiology, which remains …

The role of the immune system in autism spectrum disorder

A Meltzer, J Van de Water - Neuropsychopharmacology, 2017 - nature.com
Autism is a neurodevelopmental disorder characterized by deficits in communication and
social skills as well as repetitive and stereotypical behaviors. While much effort has focused …

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

ML Estes, AK McAllister - Nature Reviews Neuroscience, 2015 - nature.com
Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

Beyond infection-Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders

SD Bilbo, CL Block, JL Bolton, R Hanamsagar… - Experimental …, 2018 - Elsevier
Immune molecules such as cytokines and chemokines and the cells that produce them
within the brain, notably microglia, are critical for normal brain development. This recognition …

Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders

HK Hughes, E Mills Ko, D Rose… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions …

Behavioural phenotyping assays for mouse models of autism

JL Silverman, M Yang, C Lord… - Nature Reviews …, 2010 - nature.com
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1
in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria …

The role of immune dysfunction in the pathophysiology of autism

C Onore, M Careaga, P Ashwood - Brain, behavior, and immunity, 2012 - Elsevier
Autism spectrum disorders (ASD) are a complex group of neurodevelopmental disorders
encompassing impairments in communication, social interactions and restricted …

Microglial activation in young adults with autism spectrum disorder

K Suzuki, G Sugihara, Y Ouchi, K Nakamura… - JAMA …, 2013 - jamanetwork.com
Context A growing body of evidence suggests that aberrant immunologic systems underlie
the pathophysiologic characteristics of autism spectrum disorder (ASD). However, to our …

Maternal infection and immune involvement in autism

PH Patterson - Trends in molecular medicine, 2011 - cell.com
Recent studies have highlighted a connection between infection during pregnancy and the
increased risk of autism in the offspring. Parallel studies of cerebral spinal fluid, blood and …