Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and
the leading cause of cancer-related death in children and young adults. The majority of B …

Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations
identified in human cancer about 3 decades ago. Studies during the last quarter century …

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion
gene landscape in a consecutive series of 195 paediatric B-cell precursor acute …

For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is
poor, and there is a need for novel therapies to improve outcome. We screened samples …

Abstract High hyperdiploid (51–67 chromosomes) acute lymphoblastic leukemia (ALL) is
one of the most common childhood malignancies, comprising 30% of all pediatric B cell …

We sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute
lymphoblastic leukemias, the largest pediatric cancer genome sequencing effort reported to …

Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …

Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a
common event in childhood acute lymphoblastic leukemia and is caused by point mutation …

Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic
abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL) …