Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association

JW O'Sullivan, S Raghavan, C Marquez-Luna… - Circulation, 2022 - Am Heart Assoc
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart …

DK Arnett, RS Blumenthal, MA Albert… - Journal of the American …, 2019 - jacc.org
Although there has been substantial improvement in atherosclerotic cardiovascular disease
(ASCVD) outcomes in recent decades, ASCVD remains the leading cause of morbidity and …

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: executive summary: a report of the …

SM Grundy, NJ Stone, AL Bailey, C Beam… - Journal of the American …, 2019 - jacc.org
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on
the Management of Blood Cholesterol: Executive Summary: A Report of the American …

2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force …

DK Arnett, RS Blumenthal, MA Albert… - Journal of the American …, 2019 - jacc.org
Although there has been substantial improvement in atherosclerotic cardiovascular disease
(ASCVD) outcomes in recent decades, ASCVD remains the leading cause of morbidity and …

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of …

SM Grundy, NJ Stone, AL Bailey, C Beam… - Journal of the American …, 2019 - jacc.org
The recommendations listed in the present guideline are, whenever possible, evidence
based. An initial extensive evidence review, which included literature derived from research …

Clinical utility of polygenic risk scores for coronary artery disease

D Klarin, P Natarajan - Nature Reviews Cardiology, 2022 - nature.com
Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …

Statin therapy and lipoprotein (a) levels: a systematic review and meta-analysis

LM de Boer, AOJ Oorthuys, A Wiegman… - European journal of …, 2022 - academic.oup.com
Abstract Aims Lipoprotein (a)[Lp (a)] is a causal and independent risk factor for
cardiovascular disease (CVD). People with elevated Lp (a) are often prescribed statins as …

Predicting cardiovascular events in familial hypercholesterolemia: the SAFEHEART registry (Spanish Familial Hypercholesterolemia Cohort Study)

L Perez de Isla, R Alonso, N Mata… - Circulation, 2017 - Am Heart Assoc
Background: Although risk factors for atherosclerotic cardiovascular disease (ASCVD) in
familial hypercholesterolemia (FH) have been described, models for predicting incident …

Guidelines for the diagnosis and treatment of pediatric familial hypercholesterolemia 2022

M Harada-Shiba, A Ohtake, D Sugiyama… - … of atherosclerosis and …, 2023 - jstage.jst.go.jp
As atherosclerosis begins in childhood, early diagnosis and treatment of familial
hypercholesterolemia (FH) is considered necessary. The basic diagnosis of pediatric FH …

Familial hypercholesterolemia treatments: Guidelines and new therapies

FJ Raal, GK Hovingh, AL Catapano - Atherosclerosis, 2018 - Elsevier
Familial hypercholesterolemia (FH) is a genetic disorder resulting from mutations in genes
encoding proteins involved in the metabolism of low density lipoproteins (LDL) and …