Artificial intelligence-based multi-omics analysis fuels cancer precision medicine
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …
emerging that have enabled researchers to access multi-layer information from the genome …
Machine learning for multi-omics data integration in cancer
Multi-omics data analysis is an important aspect of cancer molecular biology studies and
has led to ground-breaking discoveries. Many efforts have been made to develop machine …
has led to ground-breaking discoveries. Many efforts have been made to develop machine …
Exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability: an evidence-based clinical guideline of the American …
K Manickam, MR McClain, LA Demmer, S Biswas… - Genetics in …, 2021 - nature.com
Purpose To develop an evidence-based clinical practice guideline for the use of exome and
genome sequencing (ES/GS) in the care of pediatric patients with one or more congenital …
genome sequencing (ES/GS) in the care of pediatric patients with one or more congenital …
TMB or not TMB as a biomarker: That is the question
Immune checkpoint inhibitors (ICIs) have revolutionized the landscape of therapeutic
options for many cancers. These treatments have demonstrated improved efficacy and often …
options for many cancers. These treatments have demonstrated improved efficacy and often …
Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders
Purpose We describe the clinical implementation of genome-wide DNA methylation analysis
in rare disorders across the EpiSign diagnostic laboratory network and the assessment of …
in rare disorders across the EpiSign diagnostic laboratory network and the assessment of …
[HTML][HTML] Application of next generation sequencing in laboratory medicine
The rapid development of next-generation sequencing (NGS) technology, including
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …
Advances in diagnosis of Tuberculosis: an update into molecular diagnosis of Mycobacterium tuberculosis
Tuberculosis (TB) is a major cause of deaths by a single infectious agent and has now been
a global public health problem due to increasing numbers of drug-resistant cases. Early and …
a global public health problem due to increasing numbers of drug-resistant cases. Early and …
[HTML][HTML] The complete costs of genome sequencing: a microcosting study in cancer and rare diseases from a single center in the United Kingdom
Purpose The translation of genome sequencing into routine health care has been slow,
partly because of concerns about affordability. The aspirational cost of sequencing a …
partly because of concerns about affordability. The aspirational cost of sequencing a …
Advancing personalized medicine through the application of whole exome sequencing and big data analytics
There is a growing attention toward personalized medicine. This is led by a fundamental
shift from the 'one size fits all'paradigm for treatment of patients with conditions or …
shift from the 'one size fits all'paradigm for treatment of patients with conditions or …
Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems
Antimicrobial resistance (AMR) is a significant threat to both human and animal health. The
spread of AMR bacteria and genes across systems can occur through a myriad of pathways …
spread of AMR bacteria and genes across systems can occur through a myriad of pathways …