Chiral salen–metal complexes are among the most versatile asymmetric catalysts and have
found utility in fields ranging from materials chemistry to organic synthesis. These complexes …

The addition of cyanide to a carbonyl compound to form a cyanohydrin is one of the
fundamental carbon-carbon bond forming reactions in organic chemistry1 and has …

Catalytic asymmetric synthesis has been one of the most active research areas in chemistry
(Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in …

The most important application of polymers in synthetic chemistry is the use of cross-linked
polymers in solid phase synthesis and in various sorts of “purifications”. This is emphasized …

Over the past two decades, significant advances have been made towards developing
chemically catalyzed asymmetric cyanohydrin syntheses. Preparations that were classically …

Asymmetry is ubiquitous in every part of Nature1 and has a great impact in many fields, not
only in chemistry but also even in arts. In the pharmaceutical area, asymmetry plays an …

Methods for the catalytic asymmetric synthesis of cyanohydrins derived from both aldehydes
and ketones are reviewed. Successful catalysts based on enzymes, peptides and …

In this work, we demonstrate cooperative asymmetric catalysis by a metal–organic
framework (MOF) as exemplified in the context of catalyzing cyanation of aldehydes with a …

Chiral cyanohydrins are versatile building blocks for pharmaceuticals, agrochemicals and
specialty materials. A number of efficient and successful synthetic methods have been …

A homochiral vanadium–salen based MOF with the pcu topology is constructed via in situ
synthesis under solvothermal conditions. The synthesized MOF exhibits BET surface areas …