[HTML][HTML] The Versatility of Serine Proteases from Brazilian Bothrops Venom: Their Roles in Snakebites and Drug Discovery

M Romanazzi, ETM Filardi, GMM Pires, MF Cerveja… - Biomolecules, 2025 - mdpi.com
Serine proteases are multifunctional and versatile venom components found in viper
snakes, including the Bothrops species, a widely distributed genus notorious for causing the …

Inhibitors and activators for myotoxic phospholipase A2-like toxins from snake venoms–a structural overview

GHM Salvador, FF Cardoso, B Lomonte, MRM Fontes - Biochimie, 2024 - Elsevier
Snakebite envenomations result in acute and chronic physical and psychological health
effects on their victims, leading to a substantial socio-economic burden in tropical and …

Anti-inflammatory and antiophidic effects of extract of Hymenaea eriogyne benth and structure-activity relationship prediction of the major markers in silico

A Daniele-Silva, CJL Tenório… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Hymenaea eriogyne Benth (Fabaceae) is
popularly known as" Jatobá". Despite its use in folk medicine to treat inflammatory disorders …

In vitro and in vivo anti-inflammatory and antiophidic effects of the extract and fraction of Eugenia uniflora

A Daniele-Silva, S de Sousa Ferreira… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Eugenia uniflora Linn, popularly known as
'pitanga', is a native plant endemic to Brazil that belongs to the Myrtaceae family. Its …

BthTX-I, a phospholipase A2-like toxin, is inhibited by the plant cinnamic acid derivative: Chlorogenic acid

FF Cardoso, GHM Salvador, WLG Cavalcante… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Snakebite is a significant health concern in tropical and subtropical regions, particularly in
Africa, Asia, and Latin America, resulting in more than 2.7 million envenomations and an …

Isolation of indole alkaloids and a new norneolignan of hydroethanol extract from the stem barks of Aspidosperma nitidum Benth: Preclinical evaluation of safety and …

M Torres-Rêgo, PC do Nascimento Nogueira… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Aspidosperma nitidum Benth (Apocynaceae) is a
tree found in Brazil especially in the Amazonia region, known as “carapanaúba”, being used …

[HTML][HTML] Phytochemical analysis and preclinical toxicological, antioxidant, and anti-inflammatory evaluation of hydroethanol extract from the roots of Harpalyce …

M Torres-Rêgo, AKS de Aquino-Vital… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Harpalyce brasiliana Benth (Leguminosae) is a
shrub endemic to Brazil, popularly known as “snake's root.” This species is used in folk …

[HTML][HTML] Phytochemical analysis by UPLC-QTOF-MS/MS and evaluation of antioxidant and anti-inflammatory activities of the extract and fractions from flowers of …

MJ Sarmento-Filha, M Torres-Rêgo… - South African Journal of …, 2022 - Elsevier
Cochlospermum vitifolium (pacotê) is a medicinal plant used for treatment of hypertension,
hepatitis, jaundice, hyperglycemia and inflammatory disorders. This study aimed to identify …

Renal functional and structural alterations induced by intramuscular injection of Bothrops leucurus venom

PS Hora, JRJN Junior, RD Couto, LMCC Campos… - Toxicon, 2023 - Elsevier
Acute kidney injury (AKI) is the main cause of death from Bothrops snakebite. Although
many studies have investigated the nephrotoxicity induced by other Bothrops species, no …

Aqueous Extract and Solvent Fractions of Hancornia speciosa Fruits, Rutin, and Chlorogenic Acid Attenuate the Edema, Inflammation, and Myonecrosis Caused by …

MAO Bitencourt, M Torres-Rêgo… - Revista Brasileira de …, 2024 - Springer
Snakebites are considered a neglected tropical disease in Brazil and 70% of cases of
envenomation are attributed to the genus Bothrops. The efficient therapy to treat patients is …