Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen
availability. When oxygen becomes limiting, the central transcription factors of the pathway …

Abstract Purpose of Review Hypoxia-inducible factors (HIFs) mediate the transcription of
hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we …

Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the
central nervous system rather than in the cell cycle. However, Cdk5 has been recently …

Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in
regulating various biological process in human cancers. Titin-antisense RNA1 (TTN-AS1) …

Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …

Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are
traditionally activated upon association with a regulatory subunit. For most CDKs, activation …

Background: Hepatocellular carcinoma is a highly vascularized tumor, so it is critical to study
its angiogenesis. Cancer-associated fibroblasts and enhancer of zeste homolog 2 play an …