Midbrain dopamine neurons are well known for their strong responses to rewards and their
critical role in positive motivation. It has become increasingly clear, however, that dopamine …

Delusions are the false and often incorrigible beliefs that can cause severe suffering in
mental illness. We cannot yet explain them in terms of underlying neurobiological …

Learning to predict rewards based on environmental cues is essential for survival. It is
believed that animals learn to predict rewards by updating predictions whenever the …

Animals adapt their behavior in response to informative sensory cues using multiple brain
circuits. The activity of midbrain dopaminergic neurons is thought to convey a critical …

Learning new action sequences subserves a plethora of different abilities such as escaping
a predator, playing the piano, or producing fluent speech. Proper initiation and termination of …

Highlights•Dopamine reward prediction error signals reflect model-based
information.•Model-based predictions rely on multiple features of expected …

In this review, we provide a brief overview over the current knowledge about the role of
dopamine transmission in the prefrontal cortex during learning and memory. We discuss …

Research on dopamine lies at the intersection of sophisticated theoretical and
neurobiological approaches to learning and memory. Dopamine has been shown to be …

Dopamine (DA) midbrain neurons project to several striatal and cortical target areas and are
essentially involved in a puzzling variety of important brain functions such as action …

Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social life,
particularly during adolescence, increase addiction vulnerability. Social isolation in rodents …