Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

Platelets are small anucleate cellular fragments that are released by megakaryocytes and
safeguard vascular integrity through a process termed 'haemostasis'. However, platelets …

Tumor vascular disrupting therapy has offered promising opportunities to treat cancer in
clinical practice, whereas the overall therapeutic efficacy is notably limited due to the off …

Lifelong blood production is maintained by bone marrow (BM)-residing hematopoietic stem
cells (HSCs) that are defined by two special properties: multipotency and self-renewal. Since …

Craniofacial bone defects can result from various disorders, including congenital
malformations, tumor resection, infection, severe trauma, and accidents. Successfully …

Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also
regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic …

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages.
The functioning of aged HSCs is impaired, including a declined repopulation capacity and …

We studied a subset of hematopoietic stem cells (HSCs) that are defined by elevated
expression of CD41 (CD41hi) and showed bias for differentiation toward megakaryocytes …