Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which
seriously reduces the quality of life of patients and places a heavy economic burden on their …

Through years of evolution, biological soft fibrous tissues have developed remarkable
functional properties, unique hierarchical architectures, and-most notably, an unparalleled …

Fibrillar collagen in the human cornea is integral to its function as a transparent lens of
precise curvature, and its arrangement is now well-characterised in the literature. While …

A comprehensive understanding of multiscale and multiphasic intervertebral disc mechanics
is crucial for designing advanced tissue engineered structures aiming to recapitulate native …

In the past few years, tissue-engineered total disc replacement (TE-TDR) as a possible
strategy to repair or regenerate intervertebral disc (IVD) has attracted considerable attention …

Many biological tissues have a complex hierarchical structure allowing them to function
under demanding physiological loading conditions. Structural changes caused by ageing or …

Collagen plays a key structural role in both the annulus fibrosus (AF) and nucleus pulposus
(NP) of intervertebral disks (IVDs). Changes in collagen content with degeneration suggest a …

Needle injection has been widely used in spinal therapeutic or diagnostic processes, such
as discography. The use of needles has been suspected in causing mild disc degeneration …

Abstract Background Context Annular repair devices offer a solution to recurrent disc
herniations by closing an annular defect and lowering the risk of reherniation. Given the …

Intervertebral disc (IVD) degeneration and regenerative therapies are commonly studied in
organ-culture experiments with uniaxial compressive loading. Recently, in our laboratory …