Role of CFTR in epithelial physiology

V Saint-Criq, MA Gray - Cellular and Molecular Life Sciences, 2017 - Springer
Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

[HTML][HTML] Carleman estimates for semi-discrete parabolic operators and application to the controllability of semi-linear semi-discrete parabolic equations

F Boyer, J Le Rousseau - Annales de l'Institut Henri Poincare (C) Non …, 2014 - Elsevier
In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3 Secretion

MG Lee, E Ohana, HW Park, D Yang… - Physiological …, 2012 - journals.physiology.org
Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …

Cystic ibrosis: Molecular Biology and Therapeutic Implications

FS Collins - Science, 1992 - science.org
Cystic fibrosis is the most common potentially lethal autosomal recessive disease of
Caucasians, affecting 1 in 2500 newborns. Since the recent identification of the gene that is …

An animal model for cystic fibrosis made by gene targeting

JN Snouwaert, KK Brigman, AM Latour, NN Malouf… - Science, 1992 - science.org
Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-
dependent chloride ion channel known as the cystic fibrosis transmembrane conductance …

Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis

JA Cohn, KJ Friedman, PG Noone… - … England Journal of …, 1998 - Mass Medical Soc
Background It is unknown whether genetic factors predispose patients to idiopathic
pancreatitis. In patients with cystic fibrosis, mutations of the cystic fibrosis transmembrane …

[图书][B] Physiology of the gastrointestinal tract

LR Johnson - 2006 - books.google.com
FROM THE PREFACE: The original purpose of the First Edition of Physiology of the
Gastrointestinal Tract to collect in one set of volumes the most current and comprehensive …

CFTR, mucins, and mucus obstruction in cystic fibrosis

SM Kreda, CW Davis, MC Rose - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties

DN Sheppard, DP Rich, LS Ostedgaard, RJ Gregory… - Nature, 1993 - nature.com
THE cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation-
regulated Cl-channel located in the apical membrane of epithelia1–10. Although cystic …

Submucosal glands are the predominant site of CFTR expression in the human bronchus

JF Engelhardt, JR Yankaskas, SA Ernst, Y Yang… - Nature …, 1992 - nature.com
We have used in situ hybridization and immunocytochemistry to characterize the cellular
distribution of cystic fibrosis (CF) gene expression in human bronchus. The cystic fibrosis …