New insights into atypical Alzheimer's disease in the era of biomarkers

J Graff-Radford, KXX Yong, LG Apostolova… - The Lancet …, 2021 - thelancet.com
Most patients with Alzheimer's disease present with amnestic problems; however, a
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …

Dissecting the clinical heterogeneity of early-onset Alzheimer's disease

DW Sirkis, LW Bonham, TP Johnson, R La Joie… - Molecular …, 2022 - nature.com
Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …

Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria

P Gowda, PH Reddy, S Kumar - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …

Recent update on the heterogeneity of the Alzheimer's disease spectrum

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Past, present, and future of non-invasive brain stimulation approaches to treat cognitive impairment in neurodegenerative diseases: time for a comprehensive critical …

C Sanches, C Stengel, J Godard, J Mertz… - Frontiers in Aging …, 2021 - frontiersin.org
Low birth rates and increasing life expectancy experienced by developed societies have
placed an unprecedented pressure on governments and the health system to deal …

Alzheimer's disease including focal presentations

N Villain, B Dubois - Seminars in neurology, 2019 - thieme-connect.com
Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most
frequent cause of dementia. It affects 30 million people worldwide. Current research criteria …

Pathobiological subtypes of Alzheimer disease

KA Jellinger - Dementia and Geriatric Cognitive Disorders, 2021 - karger.com
Alzheimer disease (AD), the most common form of dementia, is a heterogenous disorder
with various pathobiological subtypes. In addition to the 4 major subtypes based on the …

Language impairment in progressive supranuclear palsy and corticobasal syndrome

KA Peterson, K Patterson, JB Rowe - Journal of neurology, 2021 - Springer
Although commonly known as movement disorders, progressive supranuclear palsy (PSP)
and corticobasal syndrome (CBS) may present with changes in speech and language …

Atypical Alzheimer disease variants

AJ Polsinelli, LG Apostolova - CONTINUUM: Lifelong Learning in …, 2022 - journals.lww.com
PURPOSE OF REVIEW This article discusses the clinical, neuroimaging, and biomarker
profiles of sporadic atypical Alzheimer disease (AD) variants, including early-onset AD …

Update on tauopathies

T Lebouvier, F Pasquier, L Buee - Current opinion in neurology, 2017 - journals.lww.com
Despite the advent of novel therapeutic approaches and the increasing number of clinical
trials in tauopathies, accurate clinical diagnosis is still an unmet need and better tau …