Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues
into single-cell suspensions. While many protocols have been optimized for optimal cell …

Stem cell-independent reprogramming of differentiated cells has recently been identified as
an important paradigm for repairing injured tissues. Following periportal injury, mature …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

Muscle stem cells (MuSCs) reside in a specialized niche that ensures their regenerative
capacity. Although we know that innate immune cells infiltrate the niche in response to …

Many tissues harbor quiescent stem cells that are activated upon injury, subsequently
proliferating and differentiating to repair tissue damage. Mechanisms by which stem cells …

Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and
are critical contributors to morbidity and mortality in older people. Deciphering the molecular …

Skeletal muscle can repair and regenerate due to resident stem cells known as satellite
cells. The muscular dystrophies are progressive muscle wasting diseases underscored by …

The global loss of heterochromatin during ageing has been observed in eukaryotes from
yeast to humans, and this has been proposed as one of the causes of ageing. However, the …