[HTML][HTML] Multiomics-identified intervention to restore ethanol-induced dysregulated proteostasis and secondary sarcopenia in alcoholic liver disease

SS Singh, A Kumar, N Welch, J Sekar… - Cellular physiology …, 2021 - ncbi.nlm.nih.gov
Methods: Studies were performed in ethanol-treated differentiated C2C12 myotubes and
physiological relevance established in an ethanol-fed mouse model of alcohol-related liver …

Hypoxia sensing of β-adrenergic receptor is regulated by endosomal PI3Kγ

Y Sun, K Stenson, ML Mohan, MK Gupta… - Circulation …, 2023 - Am Heart Assoc
Background: Impaired beta-adrenergic receptor (β1 and β2AR) function following hypoxia
underlies ischemic heart failure/stroke. Activation of PI3Kγ (phosphoinositide 3-kinase γ) by …

[PDF][PDF] Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis

Y Huang, M Niu, J Jing, Z Zhang, X Zhao… - Hepatology …, 2021 - Wiley Online Library
Alcohol‐associated liver disease (ALD) is caused by alcohol metabolism's effects on the
liver. The underlying mechanisms from a metabolic view in the development of alcohol …

Renal transcriptomics reveals the carcinogenic mechanism of ethyl carbamate in musalais

W Wang, ZJ Han, D Guo, Y Xiang - OncoTargets and therapy, 2021 - Taylor & Francis
Introduction Musalais is a traditional fermented wine produced in southern Xinjiang (a
province of China) and is protected as a form of national intangible cultural heritage …

酒精性肝病合并肌肉减少症的研究进展.

王倩, 常春艳, 杨松 - Journal of Clinical Hepatology …, 2021 - search.ebscohost.com
酒精性肝病是影响我国人民健康的主要肝脏疾病之一, 约有60% 的酒精性肝病患者合并肌肉
减少症. 就酒精性肝病发生肌肉减少症的机制而言, 除了肝病患者存在食欲下降 …

Sarcopenia in chronic liver disease: novel mechanistic insights

SL Allen - 2022 - etheses.bham.ac.uk
Sarcopenia, defined as the loss of muscle mass, quality and strength commonly occurs over
the course of ageing and disease states such as chronic liver disease. In chronic liver …

Research advances in alcoholic liver disease with sarcopenia

C CHANG, Y Song - 临床肝胆病杂志, 2021 - lcgdbzz.org
Alcoholic liver disease (ALD) is one of the most common liver diseases affecting the health
of the Chinese people, and about 60% of ALD patients suffer from sarcopenia. Anorexia …

beta-blocker reverses inhibition of beta-2 adrenergic receptor resensitization by hypoxia

Y Sun, MK Gupta, K Stenson, ML Mohan, N Wanner… - bioRxiv, 2020 - biorxiv.org
Ischemia/hypoxia is major underlying cause for heart failure and stroke. Although beta-
adrenergic receptor (βAR) is phosphorylated in response to hypoxia, less is known about …