Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

We attempted to develop an experimental animal model for peripheral neuropathic pain.
Under sodium pentobarbital anesthesia, both the L 5 and L 6 spinal nerves (group 1) or the …

Partial nerve injury is the main cause of causalgiform pain disorders in humans. We present
here a novel animal model of this condition. In rats we unilaterally ligated about half of the …

Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …

IN humans, trauma to a peripheral nerve may be followed by chronic pain syndromes which
are only relieved by blockade of the effects of sympathetic impulse traffic1–4. It is presumed …

Mirror-image allodynia is a mysterious phenomenon that occurs in association with many
clinical pain syndromes. Allodynia refers to pain in response to light touch/pressure stimuli …

Neuropathic pain is defined aspain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …

The generation of knock-out and transgenic mice offers a promising approach to the
identification of novel biochemical factors that contribute to persistent pain conditions. To …

To characterize various animal models of neuropathic pain, we compared three previously
developed rat models using the same behavioral testing methods. These models involve:(1) …