Background According to recent evidence, up to 40–50% of variance in autism spectrum
disorder (ASD) liability might be determined by environmental factors. In the present paper …

Sex differences in stress responses can be found at all stages of life and are related to both
the organizational and activational effects of gonadal hormones and to genes on the sex …

Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …

To the Editor—Human organoids hold tremendous potential for biomedical applications 1–3
(Fig. 1a, b). These three-dimensional structures of cultured cells recapitulate important …

Psychiatry is enormously complex. One of its main difficulties is to articulate the relationship
between the wide assortment of factors that may cause or contribute to psychiatric disorders …

The hypothesis that offspring are affected by parental trauma or stress exposure, first noted
anecdotally, is now supported empirically by data from Holocaust survivor offspring cohorts …

Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and
environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) …

Epigenetic inheritance is another piece of the puzzle of nongenetic inheritance, although the
prevalence, sources, persistence, and phenotypic consequences of heritable epigenetic …