[HTML][HTML] Physiology and pathophysiology of carnosine

AA Boldyrev, G Aldini, W Derave - Physiological reviews, 2013 - journals.physiology.org
Abstract Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …

The biological role of carnosine and its possible applications in medicine.

S Budzeń, J Rymaszewska - Advances in clinical and experimental …, 2013 - europepmc.org
The article reviews current literature on the biological role of carnosine, its properties and
use as a supplement in periods of intense physical activity. Studies carried out on laboratory …

Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1/Nrf-2 antioxidant genes

KJS Kumar, JW Liao, JH Xiao, MG Vani, SY Wang - Toxicology in vitro, 2012 - Elsevier
Lucidone was previously reported to exhibit anti-inflammatory activity in vitro and in vivo. In
the present study, we characterized the mechanisms underlying the hepatoprotective effect …

Effects of carnosine on prooxidant–antioxidant status in heart tissue, plasma and erythrocytes of rats with isoproterenol-induced myocardial infarction

B Evran, H Karpuzoğlu, S Develi, EB Kalaz… - Pharmacological …, 2014 - Elsevier
Rats were injected with isoproterenol (ISO; 110 mg/kg, ip, 2 doses, 24 h interval) to induce
acute myocardial infarction (AMI) and were sacrificed 6 and 24 h after the last ISO injection …

Protective effects of L-carnosine on CCl4-induced hepatic injury in rats

MM Alsheblak, NM Elsherbiny, A El-Karef… - European cytokine …, 2016 - Springer
The present study was undertaken to investigate the possible protective effect of L-carnosine
(CAR), an endogenous dipeptide of alanine and histidine, on carbon tetrachloride (CCl 4) …

Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats

S Develi, B Evran, EB Kalaz, N Koçak-Toker… - Chinese journal of …, 2014 - Elsevier
Abstract Aim Nigella sativa L.(Ranunculaceae) is considered as a therapeutic plant-based
medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil …

Carnosine and taurine treatments decreased oxidative stress and tissue damage induced by d-galactose in rat liver

EB Kalaz, J Çoban, AF Aydın, I Doğan-Ekici… - Journal of physiology …, 2014 - Springer
Abstract d-galactose (GAL) causes aging-related changes and oxidative stress in the
organism. We investigated the effect of carnosine (CAR) or taurine (TAU), having antioxidant …

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

A Kumral, M Giriş, M Soluk-Tekkeşin… - Human & …, 2016 - journals.sagepub.com
Objective: Oxidative stress plays an important role in doxorubicin (DOX)-induced toxicity.
Carnosine (CAR) is a dipeptide with antioxidant properties. The aim of this study was to …

Oral or intraperitoneal binge drinking and oxidative balance in adolescent rats

F Nogales, RM Rua, ML Ojeda, ML Murillo… - Chemical research in …, 2014 - ACS Publications
Oxidative imbalance is one of the most important mechanisms of alcohol-induced injury.
Acute alcohol exposure induces a significant amount of reactive oxygen species during its …

Effect of carnosine alone or combined with α-tocopherol on hepatic steatosis and oxidative stress in fructose-induced insulin-resistant rats

S Doğru-Abbasoğlu, A Kumral, V Olgaç… - Journal of Physiology …, 2014 - Springer
A diet high in fructose (HFr) induces insulin resistance in animals. Free radicals are involved
in the pathogenesis of HFr-induced insulin resistance. Carnosine (CAR) is a dipeptide with …