In 2013 there were an estimated 584,000 deaths and 198 million clinical illnesses due to
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …

Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …

Induction of antigen-specific CD8+ T cells offers the prospect of immunization against many
infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with …

Abstract Development and Phase 3 testing of the most advanced malaria vaccine, RTS,
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …

The liver is the largest organ in the body and is generally regarded by non-immunologists as
not having lymphoid function. However, such is far from accurate. This review highlights the …

Immunization with irradiated sporozoites can protect against malaria infection and intensive
efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of …

To obtain direct evidence for a relationship between hemagglutinin (HA) cleavability and the
virulence of avian influenza A viruses, we generated a series of HA cleavage mutants from a …

The success of immunization with irradiated sporozoites is unparalleled among the current
vaccination approaches against malaria, but its mechanistic underpinnings have yet to be …

The important role played by CD8+ T lymphocytes in the control of parasitic and viral
infections, as well as tumor development, has raised the need for the development of …

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been
used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria …