Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene
expression without modifying the DNA sequence. It is commonly accepted that the …

In brief Post-ovulatory ageing of oocytes leads to poor oocyte and embryo quality as well as
abnormalities in offspring. This review provides an update on the contributions of oxidative …

All known heritable phenotypic information in animals is transmitted by direct inheritance of
nucleic acids, their covalent modifications or histone modifications that modulate expression …

Background The protozoan malaria parasite Plasmodium falciparum has a complex life
cycle during which it needs to differentiate into multiple morphologically distinct life forms. A …

Advanced maternal age is associated with a decline in oocyte quality, which often leads to
reproductive failure in humans. However, the mechanisms behind this age-related decline …

Gametogenesis involves active protein synthesis and is proposed to rely on proteostasis.
Our previous work in C. elegans indicates that germline development requires coordinated …

Oocytes spend the majority of their lifetime in a primordial state. The cellular and molecular
biology of primordial oocytes is largely unexplored; yet, it is necessary to study them to …

Protein homeostasis (proteostasis) is essential for cellular function and organismal health
and requires the concerted actions of protein synthesis, folding, transport, and turnover. In …

Significance: Stringent regulation of protein homeostasis pathways, under both
physiological and pathological conditions, is necessary for the maintenance of proteome …

The endosymbiotic Wolbachia bacteria frequently cause cytoplasmic incompatibility (CI) in
their insect hosts, where Wolbachia-infected males cross with uninfected females, leading to …