The trinity of cGAS, TLR9, and ALRs guardians of the cellular galaxy against host-derived self-DNA

V Kumar - Frontiers in Immunology, 2021 - frontiersin.org
The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma

I Lurje, W Werner, R Mohr, C Roderburg… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular Carcinoma (HCC) is a highly prevalent malignancy that develops in patients
with chronic liver diseases and dysregulated systemic and hepatic immunity. The tumor …

Host genetics of cytomegalovirus pathogenesis

E Sezgin, P An, CA Winkler - Frontiers in genetics, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) is a ubiquitous herpes virus (human herpes virus 5) with
the highest morbidity and mortality rates compared to other herpes viruses. Risk groups …

The toll-like receptor 4 polymorphism Asp299Gly is associated with an increased risk of ovarian cancer

KD Kania, D Haręża, JR Wilczyński, M Wilczyński… - Cells, 2022 - mdpi.com
Ovarian cancer (OC) is one of the most common cancers threatening women's lives around
the world. Epithelial ovarian tumors represent the most common ovarian neoplasms. Most …

Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways

P Kumari, I Saha, A Narayanan, S Narayanan… - Cell death & …, 2017 - nature.com
Cancer is a multifactorial disease and virus-mediated carcinogenesis is one of the crucial
factors, which is poorly understood. Human cytomegalovirus (HCMV) is a herpesvirus and …

TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis

A Jabłońska, M Studzińska, L Szenborn… - Scientific reports, 2020 - nature.com
Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and activate
innate and adaptive immune responses. Single nucleotide polymorphisms (SNPs) within the …

[PDF][PDF] Epidemiology of Cytomegalovirus among pregnant women in Africa

D Mhandire, S Rowland-Jones, K Mhandire… - Journal of infection in …, 2019 - ora.ox.ac.uk
Abstract Introduction: Vertical transmission of Cytomegalovirus (CMV), resulting in
congenital CMV (cCMV) infection could have disabling and potentially fatal effects on the …

Immuno-informatics approach to design a multi-epitope vaccine to combat cytomegalovirus infection

V Chauhan, MP Singh - European Journal of Pharmaceutical Sciences, 2020 - Elsevier
Human cytomegalovirus (HCMV) poses a serious public health problem causing morbidity
and mortality in transplant recipients, immunocompromised patients, and congenitally …

Influence of single-nucleotide polymorphisms in TLR3 (rs3775291) and TLR9 (rs352139) on the risk of CMV infection in kidney transplant recipients

N Redondo, I Rodríguez-Goncer, P Parra… - Frontiers in …, 2022 - frontiersin.org
Risk stratification for cytomegalovirus (CMV) infection after kidney transplantation (KT)
remains to be determined. Since endosomal toll-like receptors (TLRs) are involved in viral …

Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis

N Pandey, A Chauhan, N Raithatha, P Patel… - Microbial …, 2021 - Elsevier
Genetic polymorphism in pathogen recognition receptors tends to influence infection,
disease susceptibility, and progression. We analyzed the association of TLR4 and TLR9 …