Patient-specific inverse modeling of in vivo cardiovascular mechanics with medical image-derived kinematics as input data: concepts, methods, and applications

JH Bracamonte, SK Saunders, JS Wilson, UT Truong… - Applied Sciences, 2022 - mdpi.com
Inverse modeling approaches in cardiovascular medicine are a collection of methodologies
that can provide non-invasive patient-specific estimations of tissue properties, mechanical …

Advances in computational modelling for personalised medicine after myocardial infarction

K Mangion, H Gao, D Husmeier, X Luo, C Berry - Heart, 2018 - heart.bmj.com
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide.
Determining which patients will experience heart failure and sudden cardiac death after an …

[HTML][HTML] Physics-informed graph neural network emulation of soft-tissue mechanics

D Dalton, D Husmeier, H Gao - Computer Methods in Applied Mechanics …, 2023 - Elsevier
Modern computational soft-tissue mechanics models have the potential to offer unique,
patient-specific diagnostic insights. The deployment of such models in clinical settings has …

Surrogate models based on machine learning methods for parameter estimation of left ventricular myocardium

L Cai, L Ren, Y Wang, W Xie… - Royal Society open …, 2021 - royalsocietypublishing.org
A long-standing problem at the frontier of biomechanical studies is to develop fast methods
capable of estimating material properties from clinical data. In this paper, we have studied …

A machine learning model to estimate myocardial stiffness from EDPVR

H Babaei, EA Mendiola, S Neelakantan, Q Xiang… - Scientific Reports, 2022 - nature.com
In-vivo estimation of mechanical properties of the myocardium is essential for patient-
specific diagnosis and prognosis of cardiac disease involving myocardial remodeling …

[HTML][HTML] Emulation of cardiac mechanics using Graph Neural Networks

D Dalton, H Gao, D Husmeier - Computer Methods in Applied Mechanics …, 2022 - Elsevier
Abstract Recent progress in Graph Neural Networks (GNNs) has allowed the creation of new
methods for surrogate modelling, or emulation, of complex physical systems to a high level …

[HTML][HTML] Image-based estimation of the left ventricular cavity volume using deep learning and Gaussian process with cardio-mechanical applications

A Rabbani, H Gao, A Lazarus, D Dalton, Y Ge… - … Medical Imaging and …, 2023 - Elsevier
In this investigation, an image-based method has been developed to estimate the volume of
the left ventricular cavity using cardiac magnetic resonance (CMR) imaging data. Deep …

On the AIC-based model reduction for the general Holzapfel–Ogden myocardial constitutive law

D Guan, F Ahmad, P Theobald, S Soe, X Luo… - … and Modeling in …, 2019 - Springer
Constitutive laws that describe the mechanical responses of cardiac tissue under loading
hold the key to accurately model the biomechanical behaviour of the heart. There have been …

[HTML][HTML] Integrated Functions of Cardiac Energetics, Mechanics, and Purine Nucleotide Metabolism

R Lopez-Schenk, NL Collins, NA Schenk… - Comprehensive …, 2023 - ncbi.nlm.nih.gov
Purine nucleotides play central roles in energy metabolism in the heart. Most fundamentally,
the free energy of hydrolysis of the adenine nucleotide adenosine triphosphate (ATP) …

Effect of myofibre architecture on ventricular pump function by using a neonatal porcine heart model: from DT-MRI to rule-based methods

D Guan, J Yao, X Luo, H Gao - Royal Society open …, 2020 - royalsocietypublishing.org
Myofibre architecture is one of the essential components when constructing personalized
cardiac models. In this study, we develop a neonatal porcine bi-ventricle model with three …