The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

Stem cell ageing underlies the ageing of tissues, especially those with a high cellular
turnover. There is growing evidence that the ageing of the immune system is initiated at the …

Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells. Because HSCs must
persist for a lifetime, the balance between their proliferation and quiescence is carefully …

DNA damage induces cell-intrinsic checkpoints, including p53 and retinoblastoma (RB), as
well as upstream regulators (exonuclease 1 (EXO1), ataxia telangiectasia mutated (ATM) …

Hematopoietic stem cells (HSC) can be harmed by disease, chemotherapy, radiation, and
normal aging. We show in this study that damage also occurs in mice repeatedly treated with …

This study was designed to investigate the protective effect of curcumin against d-galactose
(d-gal)-induced premature ovarian failure (POF) in mice. A mouse POF model was induced …

Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the
well-established longevity that is a prerequisite for such function, accumulating data argue …