Modulation of intrinsically disordered protein function by post-translational modifications
A Bah, JD Forman-Kay - Journal of Biological Chemistry, 2016 - ASBMB
Post-translational modifications (PTMs) produce significant changes in the structural
properties of intrinsically disordered proteins (IDPs) by affecting their energy landscapes …
properties of intrinsically disordered proteins (IDPs) by affecting their energy landscapes …
How phosphorylation impacts intrinsically disordered proteins and their function
EA Newcombe, E Delaforge… - Essays in …, 2022 - portlandpress.com
Phosphorylation is the most common post-translational modification (PTM) in eukaryotes,
occurring particularly frequently in intrinsically disordered proteins (IDPs). These proteins …
occurring particularly frequently in intrinsically disordered proteins (IDPs). These proteins …
Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins
In eukaryotes, many DNA/RNA-binding proteins possess intrinsically disordered regions
(IDRs) with large negative charge, some of which involve a consecutive sequence of …
(IDRs) with large negative charge, some of which involve a consecutive sequence of …
[HTML][HTML] Fuzzy complexes: Specific binding without complete folding
Specific molecular recognition is assumed to require a well-defined set of contacts and
devoid of conformational and interaction ambiguities. Growing experimental evidence …
devoid of conformational and interaction ambiguities. Growing experimental evidence …
Temperature, hydrostatic pressure, and osmolyte effects on liquid–liquid phase separation in protein condensates: physical chemistry and biological implications
H Cinar, Z Fetahaj, S Cinar, RM Vernon… - … A European Journal, 2019 - Wiley Online Library
Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …
in the organization of extracellular materials and membrane‐less compartmentalization of …
Eukaryotic transcription factors: paradigms of protein intrinsic disorder
Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …
pathways, controlling, for example, cell growth, development, and stress responses. Their …
Coarse-grained residue-based models of disordered protein condensates: utility and limitations of simple charge pattern parameters
Biomolecular condensates undergirded by phase separations of proteins and nucleic acids
serve crucial biological functions. To gain physical insights into their genetic basis, we study …
serve crucial biological functions. To gain physical insights into their genetic basis, we study …
Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications
V Csizmok, JD Forman-Kay - Current opinion in structural biology, 2018 - Elsevier
Highlights•Multiple PTMs can coordinately determine a functional outcome.•Functional
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …
Charge pattern matching as a 'fuzzy'mode of molecular recognition for the functional phase separations of intrinsically disordered proteins
Biologically functional liquid–liquid phase separation of intrinsically disordered proteins
(IDPs) is driven by interactions encoded by their amino acid sequences. Little is currently …
(IDPs) is driven by interactions encoded by their amino acid sequences. Little is currently …
Connecting sequence features within the disordered C-terminal linker of Bacillus subtilis FtsZ to functions and bacterial cell division
Intrinsically disordered regions (IDRs) can function as autoregulators of folded enzymes to
which they are tethered. One example is the bacterial cell division protein FtsZ. This includes …
which they are tethered. One example is the bacterial cell division protein FtsZ. This includes …