Epithelial-mesenchymal-myofibroblast transition (EMT), a key feature in organ fibrosis, is
regulated by the state of intercellular contacts. Our recent studies have shown that an initial …

E-cadherin-mediated cell− cell interactions in the zonula adherens play an important role in
the formation of the intercellular tight junctions found in the blood− brain barrier. However, it …

Myosin-based contractility plays important roles in the regulation of epithelial functions,
particularly paracellular permeability. However, the triggering factors and the signaling …

To facilitate drug development for lung delivery, it is highly demanding to establish
appropriate airway epithelial cell models as transport barriers to evaluate pharmacokinetic …

Myosin light-chain (MLC) kinase (MLCK)-dependent increase in MLC phosphorylation has
been proposed to be a key mediator of the hyperosmotic activation of the Na+-K+-2Cl …

To develop inhaled medications, various cell culture models have been used to examine the
transcellular transport or cellular uptake properties of small molecules. For the reproducible …

Purpose We sought to identify key variables in cellular architecture and physiology that
might explain observed differences in the passive transport properties of small molecule …

Single non-confluent MDCK cells respond immediately to a sharp decrease in extracellular
Ca 2+(≤ 5 μM) with an intense reversible retraction, along with an increase in cell height …

Myosin light chain kinase (MLCK)-dependent increase in MLC phosphorylation has been
proposed to be a key mediator of the hyperosmotic activation of the Na+-K+-2Cl …

Myosin-based contractility plays important roles in the regulation of epithelial functions,
particularly paracellular permeability. However, the triggering factors and the signaling …