A new era for understanding amyloid structures and disease
MG Iadanza, MP Jackson, EW Hewitt… - … reviews Molecular cell …, 2018 - nature.com
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases
C Nediani, J Ruzzolini, A Romani, L Calorini - Antioxidants, 2019 - mdpi.com
Growing scientific literature data suggest that the intake of natural bioactive compounds
plays a critical role in preventing or reducing the occurrence of human chronic non …
plays a critical role in preventing or reducing the occurrence of human chronic non …
A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
J Marcoux, PP Mangione, R Porcari… - EMBO molecular …, 2015 - embopress.org
The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The
abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a …
abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a …
Inducing protein aggregation by extensional flow
Relative to other extrinsic factors, the effects of hydrodynamic flow fields on protein stability
and conformation remain poorly understood. Flow-induced protein remodeling and/or …
and conformation remain poorly understood. Flow-induced protein remodeling and/or …
Extracellular protein homeostasis in neurodegenerative diseases
The protein homeostasis (proteostasis) system encompasses the cellular processes that
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis
PP Mangione, R Porcari, JD Gillmore… - Proceedings of the …, 2014 - National Acad Sciences
The Ser52Pro variant of transthyretin (TTR) produces aggressive, highly penetrant,
autosomal-dominant systemic amyloidosis in persons heterozygous for the causative …
autosomal-dominant systemic amyloidosis in persons heterozygous for the causative …
Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
Abstract Dialysis-related amyloidosis (DRA), a serious complication among long-term
hemodialysis patients, is caused by amyloid fibrils of β2-microglobulin (β2m). Although high …
hemodialysis patients, is caused by amyloid fibrils of β2-microglobulin (β2m). Although high …
Energy landscapes of functional proteins are inherently risky
A Gershenson, LM Gierasch, A Pastore… - Nature chemical …, 2014 - nature.com
Evolutionary pressure for protein function leads to unavoidable sampling of conformational
states that are at risk of misfolding and aggregation. The resulting tension between …
states that are at risk of misfolding and aggregation. The resulting tension between …
Systemic amyloidosis: lessons from β2-microglobulin
M Stoppini, V Bellotti - Journal of biological chemistry, 2015 - ASBMB
β 2-Microglobulin is responsible for systemic amyloidosis affecting patients undergoing long-
term hemodialysis. Its genetic variant D76N causes a very rare form of familial systemic …
term hemodialysis. Its genetic variant D76N causes a very rare form of familial systemic …
An in vivo platform for identifying inhibitors of protein aggregation
JC Saunders, LM Young, RA Mahood… - Nature chemical …, 2016 - nature.com
Protein aggregation underlies an array of human diseases, yet only one small-molecule
therapeutic targeting this process has been successfully developed to date. Here, we …
therapeutic targeting this process has been successfully developed to date. Here, we …