Biological and functional multimorbidity—from mechanisms to management

C Langenberg, AD Hingorani, CJM Whitty - Nature Medicine, 2023 - nature.com
Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

Opportunities and obstacles for deep learning in biology and medicine

T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

[HTML][HTML] A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories

D Placido, B Yuan, JX Hjaltelin, C Zheng, AD Haue… - Nature medicine, 2023 - nature.com
Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes,
indicating a pronounced need for early detection. In this study, we applied artificial …

[HTML][HTML] Process mining for healthcare: Characteristics and challenges

J Munoz-Gama, N Martin, C Fernandez-Llatas… - Journal of Biomedical …, 2022 - Elsevier
Process mining techniques can be used to analyse business processes using the data
logged during their execution. These techniques are leveraged in a wide range of domains …

[HTML][HTML] Association between socioeconomic status and the development of mental and physical health conditions in adulthood: a multi-cohort study

M Kivimäki, GD Batty, J Pentti, MJ Shipley… - The Lancet Public …, 2020 - thelancet.com
Background Socioeconomic disadvantage is a risk factor for many diseases. We
characterised cascades of these conditions by using a data-driven approach to examine the …

GRU-ODE-Bayes: Continuous modeling of sporadically-observed time series

E De Brouwer, J Simm, A Arany… - Advances in neural …, 2019 - proceedings.neurips.cc
Modeling real-world multidimensional time series can be particularly challenging when
these are sporadically observed (ie, sampling is irregular both in time and across …

[HTML][HTML] Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

V Kuan, S Denaxas, P Patalay, D Nitsch… - The Lancet Digital …, 2023 - thelancet.com
Background Globally, there is a paucity of multimorbidity and comorbidity data, especially for
minority ethnic groups and younger people. We estimated the frequency of common disease …

[HTML][HTML] Predicting healthcare trajectories from medical records: A deep learning approach

T Pham, T Tran, D Phung, S Venkatesh - Journal of biomedical informatics, 2017 - Elsevier
Personalized predictive medicine necessitates the modeling of patient illness and care
processes, which inherently have long-term temporal dependencies. Healthcare …

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

D Ellinghaus, L Jostins, SL Spain, A Cortes… - Nature …, 2016 - nature.com
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …

[HTML][HTML] Twelve-year clinical trajectories of multimorbidity in a population of older adults

DL Vetrano, A Roso-Llorach, S Fernández… - Nature …, 2020 - nature.com
Multimorbidity—the co-occurrence of multiple diseases—is associated to poor prognosis,
but the scarce knowledge of its development over time hampers the effectiveness of clinical …