This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL
cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL …

Aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising
therapeutic target for the treatment of hypercholesterolaemia and atherosclerosis. PCSK9 …

Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly synthetized and released by
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …

Lipoprotein (a)[Lp (a)] is independently associated with CVD risk. Evolocumab, a
monoclonal antibody (mAb) to proprotein convertase subtilisin/kexin type 9 (PCSK9) …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the
regulation of cholesterol homeostasis. By binding to hepatic low-density lipoprotein (LDL) …

Clinical trials have unequivocally shown that inhibition of proprotein convertase
subtilisin/kexin type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by …

The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …