Autism spectrum disorder: focus on glutamatergic neurotransmission

M Montanari, G Martella, P Bonsi… - International Journal of …, 2022 - mdpi.com
Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment

DC Rojas - Journal of neural transmission, 2014 - Springer
Glutamate is the major excitatory neurotransmitter in the brain and may be a key
neurotransmitter involved in autism. Literature pertaining to glutamate and autism or related …

A randomized controlled pilot trial of oral N-acetylcysteine in children with autism

AY Hardan, LK Fung, RA Libove, TV Obukhanych… - Biological …, 2012 - Elsevier
BACKGROUND: An imbalance in the excitatory/inhibitory systems with abnormalities in the
glutamatergic pathways has been implicated in the pathophysiology of autism. Furthermore …

Gene–environment interactions in developmental neurotoxicity: a case study of synergy between chlorpyrifos and CHD8 knockout in human brainspheres

S Modafferi, X Zhong, A Kleensang… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Autism spectrum disorder (ASD) is a major public health concern caused by
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …

Autism and nutrition: the role of the gut–brain axis

MMH van De Sande, VJ van Buul… - Nutrition research …, 2014 - cambridge.org
Autism spectrum disorder (ASD) is characterised by deficits in the ability to socialise,
communicate and use imagination, and displays of stereotypical behaviour. It is widely …

Profiles of urine and blood metabolomics in autism spectrum disorders

N Likhitweerawong, C Thonusin… - Metabolic brain …, 2021 - Springer
Early diagnosis and treatment for autism spectrum disorder (ASD) pose challenges. The
current diagnostic approach for ASD is mainly clinical assessment of patient behaviors …

Amino acids, B vitamins, and choline may independently and collaboratively influence the incidence and core symptoms of autism spectrum disorder

L Jennings, R Basiri - Nutrients, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a developmental disorder of variable severity,
characterized by difficulties in social interaction, communication, and restricted or repetitive …

Glutamatergic dysfunction and synaptic ultrastructural alterations in schizophrenia and autism spectrum disorder: Evidence from human and rodent studies

A Eltokhi, A Santuy, A Merchan-Perez… - International journal of …, 2020 - mdpi.com
The correlation between dysfunction in the glutamatergic system and neuropsychiatric
disorders, including schizophrenia and autism spectrum disorder, is undisputed. Both …

N-acetylcysteine as an adjunctive therapy to risperidone for treatment of irritability in autism: a randomized, double-blind, placebo-controlled clinical trial of efficacy …

M Nikoo, H Radnia, M Farokhnia… - Clinical …, 2015 - journals.lww.com
Objectives According to the proposed interference of N-acetylcysteine (NAC) with
pathophysiologic processes of autistic disorders (ADs), we aimed to assess the …

The gut-immune-brain axis in autism spectrum disorders; a focus on amino acids

JHJ van Sadelhoff, P Perez Pardo, J Wu… - Frontiers in …, 2019 - frontiersin.org
Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that affect
communication and social behavior. Besides social deficits, systemic inflammation …