The current unidimensional paradigm of kidney disease detection is incompatible with the
complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has …

For over 70 years, serum creatinine has remained the primary index for detection and
monitoring of kidney disease. Tubulointerstitial damage and fibrosis are highly prognostic for …

Background Urinary protein quantification is critical for assessing the severity of chronic
kidney disease (CKD). However, the current procedure for determining the severity of CKD …

Abstract The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter,
longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 …

Serum creatinine concentration, the classical biomarker of chronic kidney disease (CKD) in
cats, has important limitations that decrease its value as a biomarker of early CKD. Recently …

Importance Among patients who had acute kidney injury (AKI) during hospitalization, there is
a need to improve risk prediction such that those at highest risk for subsequent loss of …

Abstract Background The EFLM Task and Finish Group Urinalysis has updated the ECLM
European Urinalysis Guidelines (2000) on urinalysis and urine bacterial culture, to improve …

Background The individual course of CKD may vary, and improved methods for identifying
which patients will experience short-term eGFR loss are needed. Assessing urinary Dickkopf …

Background Sensitive and specific biomarkers are needed to provide better biologic insight
into the risk of incident and progressive CKD. However, studies have been limited by sample …

The development of omics technologies has driven a profound expansion in the scale of
biological data and the increased complexity in internal dimensions, prompting the …