The new generation of monoamine oxidase inhibitors
S Mitsuhashi, T Kojima, N Nakanishi, T Fujimoto… - Progress in Drug …, 1992 - Springer
The development of monoamine oxidase (MAO) inhibitors has followed a winding path. At
the origin was the finding of EA Zeller that iproniazid, a hydrazine derivative designed to …
the origin was the finding of EA Zeller that iproniazid, a hydrazine derivative designed to …
Oxidation of amines by flavoproteins
PF Fitzpatrick - Archives of biochemistry and biophysics, 2010 - Elsevier
Many flavoproteins catalyze the oxidation of primary and secondary amines, with the transfer
of a hydride equivalent from a carbon–nitrogen bond to the flavin cofactor. Most of these …
of a hydride equivalent from a carbon–nitrogen bond to the flavin cofactor. Most of these …
[10] Mechanism-based enzyme inactivators
RB Silverman - Methods in enzymology, 1995 - Elsevier
Publisher Summary An enzyme inactivator, in general, is a compound that produces
irreversible inhibition of the enzyme—that is, it irreversibly prevents the enzyme from …
irreversible inhibition of the enzyme—that is, it irreversibly prevents the enzyme from …
Radical ideas about monoamine oxidase
RB Silverman - Accounts of chemical research, 1995 - ACS Publications
Monoamine oxidase (MAO) catalyzes the oxidation of a variety of amine neurotransmitters,
such as norepinephrine, serotonin, and dopamine. It belongs to a family of enzymes known …
such as norepinephrine, serotonin, and dopamine. It belongs to a family of enzymes known …
[PDF][PDF] Selective inhibitors of monoamine oxidase (MAO‐A and MAO‐B) as probes of its catalytic site and mechanism
AS Kalgutkar, N Castagnoli Jr, B Testa - Medicinal research reviews, 1995 - natmedlib.uz
A. Specificities of the MAOs........................................................ B. Kinetics of Enzyme-Catalyzed
Reactions........................... C. Mechanism of MAO-Catalyzed Oxidations of Amines.............. IV …
Reactions........................... C. Mechanism of MAO-Catalyzed Oxidations of Amines.............. IV …
A computational study on the amine-oxidation mechanism of monoamine oxidase: Insight into the polar nucleophilic mechanism
The proposed polar nucleophilic mechanism of MAO was investigated using quantum
chemical calculations employing the semi-empirical PM3 method. In order to mimic the …
chemical calculations employing the semi-empirical PM3 method. In order to mimic the …
Radical azidonation of benzylic positions with iodonium azide
C Viuf, M Bols - Angewandte Chemie, 2001 - Wiley Online Library
Radical Azidonation of Benzylic Positions with Iodonium Azide - Viuf - 2001 - Angewandte
Chemie - Wiley Online Library Skip to Article Content Skip to Article Information Wiley Online …
Chemie - Wiley Online Library Skip to Article Content Skip to Article Information Wiley Online …
Inactivation of monoamine oxidase by (aminomethyl) cubane. First evidence for an. alpha.-amino radical during enzyme catalysis
RB Silverman, JP Zhou, PE Eaton - Journal of the American …, 1993 - ACS Publications
Monoamine oxidase (EC 1.4. 3.4; MAO), a flavin-dependent enzyme that catalyzes the
oxidation of a variety of amine neurotransmitters, exists in two isozymic forms known as MAO …
oxidation of a variety of amine neurotransmitters, exists in two isozymic forms known as MAO …
The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism
G Maret, B Testa, P Jenner, NE Tayar… - Drug metabolism …, 1990 - Taylor & Francis
The motor disabilities characterising Parkinson's disease are due to a primary loss of
neurons in zona compacta of substantia nigra [l-31, resulting in dramatic decrease in the …
neurons in zona compacta of substantia nigra [l-31, resulting in dramatic decrease in the …
Ethylene biosynthesis: processing of a substrate analog supports a radical mechanism for the ethylene-forming enzyme
MC Pirrung, J Cao, J Chen - Chemistry & biology, 1998 - cell.com
Background: The chemical mechanism of the final step of ethylene biosynthesis (the
conversion of 1-aminocyclopropanecarboxylic acid, ACC 1 to ethylene by ACC oxidase, the …
conversion of 1-aminocyclopropanecarboxylic acid, ACC 1 to ethylene by ACC oxidase, the …