Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

Nowadays we understand cell membranes not as a simple double lipid layer but as a
collection of complex and dynamic protein–lipid structures and microdomains that serve as …

Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of
malignancies, but its use is limited by dose-dependent cardiotoxicity. A recent genome-wide …

Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids
with well-recognized structural roles in cellular membranes. They are also signaling lipids …

C2 domains are membrane-binding modules that share a common overall fold: a single
compact Greek-key motif organized as an eight-stranded anti-parallel β-sandwich consisting …

C2 domains are a ubiquitous structural module and many of them function in Ca2+-
dependent membrane binding and thereby serve as Ca2+ effectors for divergent Ca2+ …

Phosphatidic acid is the simplest (diacyl) glycerophospholipid present in cells and is now a
well established second messenger with direct biological functions. It is specifically …

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic
acid (PA). Mammalian DGK consists of ten isozymes (α–κ) and governs a wide range of …

1M. G. kholodny Institute of Botany, National academy of Sciences of Ukraine, kyiv;
2Palladin Institute of Biochemistry, National academy of Sciences of Ukraine, kyiv; e-mail …

Protein kinase C (PKC) is a member of a family of Ser/Thr phosphotransferases that are
involved in many cellular signaling pathways. These enzymes possess two regulatory …