Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …

Despite strong evidence of effectiveness, colorectal cancer (CRC) screening remains
underused. Currently, there are several options for CRC screening, each with its own …

Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically
detected late and at an inoperable stage. Early or incidental detection is associated with …

A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …

Importance Colorectal cancer is the third leading cause of cancer death for both men and
women, with an estimated 52 980 persons in the US projected to die of colorectal cancer in …

To chart cell composition and cell state changes that occur during the transformation of
healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single …

Colorectal cancer (CRC) is the third most common cancer in men and women in the United
States. CRC screening efforts are directed toward removal of adenomas and sessile …

Over the past decade, various liquid biopsy techniques have emerged as viable alternatives
to the analysis of traditional tissue biopsy samples. Such surrogate 'biopsies' offer numerous …