Therapeutic effects of lactoferrin in ocular diseases: from dry eye disease to infections

A Vagge, C Senni, F Bernabei, M Pellegrini… - International journal of …, 2020 - mdpi.com
Lactoferrin is a naturally occurring iron-binding glycoprotein, produced and secreted by
mucosal epithelial cells and neutrophils in various mammalian species, including humans. It …

COVID-19 and dry eye

S Koh, MK Rhee - Eye & Contact Lens, 2021 - journals.lww.com
The aim of this article is to review the literature on the impact of coronavirus disease 2019
(COVID-19) on dry eye disease (DED). A literature search on dry eye and COVID-19 was …

[HTML][HTML] Neutrophils and neutrophil extracellular trap components: Emerging biomarkers and therapeutic targets for age-related eye diseases

I Martínez-Alberquilla, X Gasull, P Pérez-Luna… - Ageing Research …, 2022 - Elsevier
Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration,
and diabetic retinopathy, represent a major global health issue based on their increasing …

[HTML][HTML] Biomedical applications of lactoferrin on the ocular surface

U Regueiro, M López-López, R Varela-Fernández… - Pharmaceutics, 2023 - mdpi.com
Lactoferrin (LF) is a first-line defense protein with a pleiotropic functional pattern that
includes anti-inflammatory, immunomodulatory, antiviral, antibacterial, and antitumoral …

Alternative therapeutic interventions: antimicrobial peptides and small molecules to treat microbial keratitis

PK Jadi, P Sharma, B Bhogapurapu, S Roy - Frontiers in Chemistry, 2021 - frontiersin.org
Microbial keratitis is a leading cause of blindness worldwide and results in unilateral vision
loss in an estimated 2 million people per year. Bacteria and fungus are two main etiological …

Lactoferrin and its nano-formulations in rare eye diseases

J Singh, M Sharma, N Jain, I Aftab… - Indian Journal of …, 2022 - journals.lww.com
Lactoferrin (LF) is an iron-binding glycoprotein released from mucous secreting cells and
neutrophils. LF can be used in a broad range of eye diseases related to the retina, cornea …

Characterization of lactobionic acid evidencing its potential for food industry application

T Cardoso, C Marques, AR Sotiles… - Journal of Food …, 2019 - Wiley Online Library
The chemical configuration of the lactobionic acid (LBA) evidences its potential properties,
among which the antioxidant, antimicrobial, and chelating activities stand out in the …

Platelet-rich plasma lysate for treatment of eye surface diseases

L Merolle, B Iotti, P Berni, E Bedeschi, K Boito… - JoVE (Journal of …, 2022 - jove.com
Various ocular surface diseases are treated with blood-derived eye drops. Their use has
been introduced in clinical practice because of their metabolite and growth factor content …

Development, Optimization, and Clinical Relevance of Lactoferrin Delivery Systems: A Focus on Ocular Delivery

E Ponzini, G Astolfi, R Grandori, S Tavazzi, P Versura - Pharmaceutics, 2024 - mdpi.com
Lactoferrin (Lf), a multifunctional protein found abundantly in secretions, including tears,
plays a crucial role in ocular health through its antimicrobial, immunoregulatory, anti …

[HTML][HTML] Rabbit models of dry eye disease: comparative analysis

V Baranauskas, J Daukantaitė… - International Journal of …, 2023 - ncbi.nlm.nih.gov
AIM To report ocular changes in rabbits after the implementation of three different induction
methods to create dry eye (DE) conditions and provides evidence of DE-related disease …