Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Polygenic risk alters the penetrance of monogenic kidney disease
Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and
environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A …
environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A …
Genomic Insights for Personalized Care: Motivating At-Risk Individuals Toward Evidence-Based Health Practices
Lung cancer and tobacco use pose significant global health challenges and require a
comprehensive translational roadmap for improved prevention strategies. We propose the …
comprehensive translational roadmap for improved prevention strategies. We propose the …
[HTML][HTML] Leveraging genetic correlations and multiple populations to improve genetic risk prediction for non-European populations
The disparity in genetic risk prediction accuracy between European and non-European
individuals highlights a critical challenge in health inequality. To bridge this gap, we …
individuals highlights a critical challenge in health inequality. To bridge this gap, we …
Ensembled best subset selection using summary statistics for polygenic risk prediction
Polygenic risk scores (PRS) enhance population risk stratification and advance
personalized medicine, yet existing methods face a tradeoff between predictive power and …
personalized medicine, yet existing methods face a tradeoff between predictive power and …