Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …
thus for maintaining genome stability and cellular lifespan. This process requires …
Telomere replication: solving multiple end replication problems
E Bonnell, E Pasquier, RJ Wellinger - Frontiers in Cell and …, 2021 - frontiersin.org
Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …
end protection from unwarranted fusions, recombination, and degradation in order to …
The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells
M Barazas, S Annunziato, SJ Pettitt, I de Krijger… - Cell reports, 2018 - cell.com
Selective elimination of BRCA1-deficient cells by inhibitors of poly (ADP-ribose) polymerase
(PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This …
(PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This …
The structure of human CST reveals a decameric assembly bound to telomeric DNA
CJ Lim, AT Barbour, AJ Zaug, KJ Goodrich, AE McKay… - Science, 2020 - science.org
The CTC1-STN1-TEN1 (CST) complex is essential for telomere maintenance and resolution
of stalled replication forks genome-wide. Here, we report the 3.0-angstrom cryo–electron …
of stalled replication forks genome-wide. Here, we report the 3.0-angstrom cryo–electron …
[HTML][HTML] Structure and function of the telomeric CST complex
C Rice, E Skordalakes - Computational and structural biotechnology …, 2016 - Elsevier
Telomeres comprise the ends of eukaryotic chromosomes and are essential for cell
proliferation and genome maintenance. Telomeres are replicated by telomerase, a …
proliferation and genome maintenance. Telomeres are replicated by telomerase, a …
Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST
Abstract Human CST (CTC1–STN1–TEN1) is a ssDNA-binding complex that helps resolve
replication problems both at telomeres and genome-wide. CST resembles Replication …
replication problems both at telomeres and genome-wide. CST resembles Replication …
Targeting human telomeric higher-order DNA: dimeric G-quadruplex units serve as preferred binding site
Long human telomeric fragments can form stable, higher-order G-quadruplex structures,
recently identified in human cells, which are potential drug targets. However, there are very …
recently identified in human cells, which are potential drug targets. However, there are very …
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch
NF Lue, J Chan, WE Wright, J Hurwitz - Nature communications, 2014 - nature.com
Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding
complex, may regulate primase-Pol α (PP) activity at telomeres constitutively, and at other …
complex, may regulate primase-Pol α (PP) activity at telomeres constitutively, and at other …
[HTML][HTML] Emerging roles of CST in maintaining genome stability and human disease
JA Stewart, Y Wang, SM Ackerson… - Frontiers in bioscience …, 2018 - ncbi.nlm.nih.gov
Abstract The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding
protein that shares homology with RPA and interacts with DNA polymerase alpha/primase …
protein that shares homology with RPA and interacts with DNA polymerase alpha/primase …
Structural insights into telomere protection and homeostasis regulation by yeast CST complex
Y Ge, Z Wu, H Chen, Q Zhong, S Shi, G Li… - Nature Structural & …, 2020 - nature.com
Abstract Budding yeast Cdc13–Stn1–Ten1 (CST) complex plays an essential role in
telomere protection and maintenance. Despite extensive studies, only structural information …
telomere protection and maintenance. Despite extensive studies, only structural information …