Self-healing injectable hydrogels for tissue regeneration

P Bertsch, M Diba, DJ Mooney… - Chemical …, 2022 - ACS Publications
Biomaterials with the ability to self-heal and recover their structural integrity offer many
advantages for applications in biomedicine. The past decade has witnessed the rapid …

Considerations for polymers used in ocular drug delivery

MM Allyn, RH Luo, EB Hellwarth… - Frontiers in …, 2022 - frontiersin.org
Purpose Age-related eye diseases are becoming more prevalent. A notable increase has
been seen in the most common causes including glaucoma, age-related macular …

Ocular drug delivery to the retina: current innovations and future perspectives

HM Kim, SJ Woo - Pharmaceutics, 2021 - mdpi.com
Treatment options for retinal diseases, such as neovascular age-related macular
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …

Advances in ocular drug delivery systems

JJ Kang-Mieler, KM Rudeen, W Liu, WF Mieler - Eye, 2020 - nature.com
Recent advances in pharmacological agents have led to successful treatment of a variety of
retinal diseases such as neovascular age-related macular degeneration (AMD), diabetic …

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

I Seah, X Zhao, Q Lin, Z Liu, SZZ Su, YS Yuen… - Eye, 2020 - nature.com
Anti-vascular endothelial growth factors (anti-VEGF) have become the most common
treatment modality for many retinal diseases. These include neovascular age-related …

Review of contemporary self-assembled systems for the controlled delivery of therapeutics in medicine

LL Osorno, AN Brandley, DE Maldonado, A Yiantsos… - Nanomaterials, 2021 - mdpi.com
The novel and unique design of self-assembled micro and nanostructures can be tailored
and controlled through the deep understanding of the self-assembly behavior of amphiphilic …

Ocular delivery of therapeutic proteins: a review

DH Shastri, AC Silva, H Almeida - Pharmaceutics, 2023 - mdpi.com
Therapeutic proteins, including monoclonal antibodies, single chain variable fragment
(ScFv), crystallizable fragment (Fc), and fragment antigen binding (Fab), have accounted for …

Novel therapies for the prevention of fibrosis in glaucoma filtration surgery

CG Shao, NR Sinha, RR Mohan, AD Webel - Biomedicines, 2023 - mdpi.com
Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration
surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but …

Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems

KY Wu, M Joly-Chevrier, D Akbar, SD Tran - Pharmaceutics, 2023 - mdpi.com
Posterior segment eye diseases present a challenge in treatment due to the complex
structures in the eye that serve as robust static and dynamic barriers, limiting the penetration …

Six-month sustained delivery of anti-VEGF from in-situ forming hydrogel in the suprachoroidal space

JH Jung, SS Kim, H Chung, A Hejri… - Journal of Controlled …, 2022 - Elsevier
Patients with wet age-related macular degeneration (AMD) require intravitreal injections of
bevacizumab (Bev) or other drugs, often on a monthly basis, which is a burden on the …