Natural products frequently exert pharmacological activities. The present review gives an
overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, eg …

Simple Summary In this review article, we present the fascinating story of sirolimus
(rapamycin), a drug known to be able to induce fetal hemoglobin, and for this reason of great …

β-thalassemias are among the most common inherited hemoglobinopathies worldwide and
are the result of autosomal mutations in the gene encoding β-globin, causing an absence or …

Human DNA methylation data have previously been used to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Subsequent studies demonstrate that similar …

Background The major therapeutic benefit of hydroxyurea, the only FDA-approved
pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin …

Sirolimus for Treatment of β-Thalassemia: From Pre-Clinical Studies to the Design of Clinical
Trials Page 1 Health Education and Public Health 425 Health Educ Public Health 2021, 4:3 …

The involvement of microRNAs in the control of repressors of human γ-globin gene
transcription has been firmly demonstrated, as described for the miR-486-3p mediated down …

DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …

Since the identification of microRNAs (miRNAs) involved in the regulation of Cystic Fibrosis
Transmembrane Conductance Regulator (CFTR) gene, miRNAs known to down-regulate …

Transcription factors are recognized as the master regulators of gene expression.
Interestingly, about 10% of the transcription factors described in mammals are up to date …