Phagemids are filamentous-phage-derived vectors containing the replication origin of a
plasmid. Phagemids usually encode no or only one kind of coat proteins. Other structural …

Phage display technology is an emerging drug discovery tool. Using that approach, short
peptides that mimic part of a carbohydrate's conformation are selected by screening a …

Chimeric antigen receptor (CAR) T cell technology has ushered in a new era of
immunotherapy, enabling the targeting of a broad range of surface antigens, surpassing the …

Humans lack the enzyme that produces the sialic acid N-glycolyl neuraminic acid (Neu5Gc),
but several lines of evidence have shown that Neu5Gc can be taken up by mammalian food …

Yeast surface display emerged as a viable tool for the generation of human and murine
monoclonal antibodies. This platform technology enables the careful definition of selection …

Chimeric antigen receptor (CAR) T cells have emerged as a powerful immunotherapeutic
tool against certain hematological malignancies but a significant proportion of patients either …

Immunotherapy is a growing field in cancer research. A privileged tumor-associated antigen
that has received much attention is N-glycolyl (NeuGc) GM3. This ganglioside is present in …

Gangliosides containing the N-glycolyl (NGc) form of sialic acid are tumor-associated
antigens and promising candidates for cancer therapy. We previously generated the murine …

Attached to proteins, lipids, or forming long, complex chains, glycans represent the most
versatile post-translational modification in nature and surround all human cells. Unique …

We have previously reported the isolation of a novel single-chain variable fragment (scFv)
against vascular endothelial growth factor (VEGF), from a phage-displayed human antibody …