Nowadays, the pathophysiology of several central nervous system (CNS) disorders is still
poorly understood, making difficult the identification of efficient treatments. CNS damages …

Neural stem cells (NSCs) persist in the dentate gyrus of the hippocampus into adulthood
and are essential for both neurogenesis and neural circuit integration. Exosomes have also …

One of the most significant risk variants for Parkinson's disease (PD), rs356182, is located at
the PD-associated locus near the alpha-synuclein (α-syn) encoding gene, SNCA. SNCA …

Aim: To study the effects of DNMT1 overexpression on transcript levels of genes
dysregulated in schizophrenia and on genome-wide methylation patterns. Materials & …

Nitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a
modulator of the signal transducer and activator of transcription 3 (STAT3) activity. In our …

Data on schizophrenia (SZ), epilepsy (EPD) and bipolar disorders (BPD) suggested an
association of DNMT1 overexpression whereas certain variants of the gene were predicted …

Microengineering is increasingly being used for controlling the microenvironment of stem
cells. Here, a novel method for fabricating structures with subcellular dimensions in …

Abstract Hereditary Sensory and Autonomic Neuropathy Type 1E (HSAN1E) is a rare
autosomal dominant neurological disorder due to missense mutations in DNA …

Background Microplastic infection is now one of the world's key environmental concerns.
The most significant causes of microplastic contamination in aquatic ecosystems are coastal …

Abstract DNMT1 Y495C is the most common mutation associated with hereditary sensory
and autonomic neuropathy type 1E, and dementia. Here we employed non-homologous …