Unraveling the molecular nexus between GPCRs, ERS, and EMT

N Kumari, S Reabroi, BJ North - Mediators of inflammation, 2021 - Wiley Online Library
G protein‐coupled receptors (GPCRs) represent a large family of transmembrane proteins
that transduce an external stimulus into a variety of cellular responses. They play a critical …

The underlying mechanisms of noncoding RNAs in the chemoresistance of hepatocellular carcinoma

M Wang, F Yu, X Chen, P Li, K Wang - Molecular Therapy-Nucleic Acids, 2020 - cell.com
Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies.
Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of …

LncRNA GClnc1 promotes proliferation and invasion of bladder cancer through activation of MYC

C Zhuang, Q Ma, C Zhuang, J Ye, F Zhang… - The FASEB …, 2019 - Wiley Online Library
Various studies demonstrate that long noncoding RNAs (IncRNAs) act as oncogenes or
tumor suppressors in cancer. However, the function of IncRNAs in bladder cancer still …

Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen

SJ Chang, SC Jin, X Jiao, JE Galan - PLoS Pathogens, 2019 - journals.plos.org
Typhoid toxin is a virulence factor for Salmonella Typhi and Paratyphi, the cause of typhoid
fever in humans. This toxin has a unique architecture in that its pentameric B subunit, made …

The role of CD133 in hepatocellular carcinoma

F Liu, Y Qian - Cancer Biology & Therapy, 2021 - Taylor & Francis
Cancer stem cells (CSCs) represent a small subpopulation of cells found within tumors that
exhibit properties of self-renewal, like normal stem cells. CSCs have been defined as a …

Mechanism of long noncoding RNAs as transcriptional regulators in cancer

Y Huang, Q Guo, XP Ding, X Wang - RNA biology, 2020 - Taylor & Francis
Dysregulation of gene expression, often interpreted by gene transcription as an endpoint
response, is tightly associated with human cancer. Long noncoding RNAs (lncRNAs) …

[HTML][HTML] LncRNAs link cancer stemness to therapy resistance

J Yue, Y Wu, L Qiu, R Zhao, M Jiang… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) are a cellular subpopulation accelerating cancer cell growth,
invasion and metastasis and survival. After chemoradiotherapy, CSCs are enriched because …

Unleashing the diagnostic, prognostic and therapeutic potential of the neuronostatin/GPR107 system in prostate cancer

P Saez-Martinez, JM Jimenez-Vacas… - Journal of Clinical …, 2020 - mdpi.com
Certain components of the somatostatin-system play relevant roles in Prostate Cancer
(PCa), whose most aggressive phenotype (Castration-Resistant-PCa (CRPC)) remains …

lncRNA SNHG9 enhances liver cancer stem cell self-renewal and tumorigenicity by negatively regulating PTEN expression via recruiting EZH2

S Yang, X Ruan, B Hu, J Tu, H Cai - Cell and Tissue Research, 2023 - Springer
Liver cancer stem cell (CSC) self-renewal and tumorigenesis are important causes of
hepatocellular carcinoma (HCC) recurrence. We purposed to investigate the function of long …

Changes in expression of orphan receptors GPR99 and GPR107 during the development and establishment of hypertension in spontaneously hypertensive rats

L Calderón-Zamora, A Canizalez-Román… - Journal of Receptors …, 2021 - Taylor & Francis
Hypertension is a disease, which in spite of existing treatments continues to have high
morbidity and mortality, which suggests that there are other mechanisms involved in this …