Insights into the pharmacogenetics of tacrolimus pharmacokinetics and pharmacodynamics
M Brunet, M Pastor-Anglada - Pharmaceutics, 2022 - mdpi.com
The influence of pharmacogenetics in tacrolimus pharmacokinetics and pharmacodynamics
needs further investigation, considering its potential in assisting clinicians to predict the …
needs further investigation, considering its potential in assisting clinicians to predict the …
Tacrolimus-pharmacokinetic considerations for clinicians
K Schutte-Nutgen, G Tholking… - Current drug …, 2018 - ingentaconnect.com
Background: The calcineurin inhibitor tacrolimus (Tac) is an integral part of the standard
immunosuppressive regimen after renal transplantation (RTx). However, clinical …
immunosuppressive regimen after renal transplantation (RTx). However, clinical …
Pharmacogenetics of membrane transporters of tacrolimus in solid organ transplantation
C Tron, F Lemaitre, C Verstuyft, A Petitcollin… - Clinical …, 2019 - Springer
Membrane transporters play an essential role in the pharmacokinetics of drugs as they
mediate exchanges between biological compartments. Tacrolimus is characterized by wide …
mediate exchanges between biological compartments. Tacrolimus is characterized by wide …
Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian …
WS Oetting, B Wu, DP Schladt, W Guan… - The …, 2018 - nature.com
The immunosuppressant tacrolimus (TAC) is metabolized by both cytochrome P450 3A4
(CYP3A4) and CYP3A5 enzymes. It is common for European Americans (EA) to carry two …
(CYP3A4) and CYP3A5 enzymes. It is common for European Americans (EA) to carry two …
Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients
WS Oetting, B Wu, DP Schladt, W Guan… - …, 2018 - Taylor & Francis
Aim: Multiple genetic variants have been associated with variation in tacrolimus (TAC)
trough concentrations. Unfortunately, additional studies do not confirm these associations …
trough concentrations. Unfortunately, additional studies do not confirm these associations …
[HTML][HTML] A systematic review and meta-analysis recite the efficacy of Tacrolimus treatment in renal transplant patients in association with genetic variants of CYP3A5 …
PM Chauhan, RJ Hemani, ND Solanki… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Tacrolimus is an immunosuppressant with a narrow therapeutic index and pharmacokinetic
variability. This variability may be attributed to genetic variants in gene CYP3A5 associated …
variability. This variability may be attributed to genetic variants in gene CYP3A5 associated …
Tacrolimus diffusion across the peripheral mononuclear blood cell membrane: impact of drug transporters
C Tron, M Allard, A Petitcollin… - Fundamental & …, 2019 - Wiley Online Library
Measuring tacrolimus (TAC) concentration in peripheral blood mononuclear cells (PBMCs)
could better reflect the drug effect on its target (calcineurin (CaN) in lymphocytes) than whole …
could better reflect the drug effect on its target (calcineurin (CaN) in lymphocytes) than whole …
The influence of recipient SLCO1B1 rs2291075 polymorphism on tacrolimus dose–corrected trough concentration in the early period after liver transplantation
Y Wu, F Fang, Z Wang, P Wen, J Fan - European Journal of Clinical …, 2021 - Springer
Purpose To explore the relationship between rs2291075 polymorphism in SLCO1B1 gene,
which encodes an influx transmembrane protein transporter, and tacrolimus dose–corrected …
which encodes an influx transmembrane protein transporter, and tacrolimus dose–corrected …
Tacrolimus—why pharmacokinetics matter in the clinic
L Henkel, U Jehn, G Thölking, S Reuter - Frontiers in Transplantation, 2023 - frontiersin.org
The calcineurin inhibitor (CNI) Tacrolimus (Tac) is the most prescribed immunosuppressant
drug after solid organ transplantation. After renal transplantation (RTx) approximately 95% of …
drug after solid organ transplantation. After renal transplantation (RTx) approximately 95% of …
Drug transporters are implicated in the diffusion of tacrolimus into the T lymphocyte in kidney and liver transplant recipients: Genetic, mRNA, protein expression, and …
G Coste, F Robin, J Chemouny, C Tron… - Drug Metabolism and …, 2022 - Elsevier
Because of a narrow therapeutic index and a wide inter-and intra-patient variability,
therapeutic drug monitoring of the immunosuppressant drug tacrolimus (TAC) based on …
therapeutic drug monitoring of the immunosuppressant drug tacrolimus (TAC) based on …