The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical
and psychiatric conditions such as forms of obesity and eating disorders. Although feeding …

Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …

Sigma1 (also known as sigma-1 receptor, Sig1R, σ1 receptor) is a unique pharmacologically
regulated integral membrane chaperone or scaffolding protein. The majority of publications …

Background Reduced dopamine D2 receptor (D2R) ligand binding has repeatedly been
demonstrated in the striatum of humans with alcohol use disorder (AUD). The attenuated …

Compulsive eating behaviour is a transdiagnostic construct observed in certain forms of
obesity and eating disorders, as well as in the proposed construct of 'food addiction' …

Alcohol use disorder (AUD) constitutes a major burden to global health. Recently, the
translational success of animal models of AUD has come under increased scrutiny. Efforts to …

Pharmacological treatments for alcohol use disorder (AUD) are few in number and often
ineffective, despite the significant research carried out so far to better comprehend the …

Background: Quetiapine, an atypical antipsychotic endowed with weak dopamine
antagonist, potent 5-HT2A-blocking, partial 5-HT1A-agonist, anti-H1 histamine, adrenolytic …

In this paper, the benzo-cracking approach was applied to the potent sigma1 (σ1) receptor
antagonist 1 to afford the less conformationally constrained 1, 3-dioxane derivatives 2 and 3 …