Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …

Neurodegenerative diseases originate from neuronal loss in the central nervous system
(CNS). These debilitating diseases progress with age and have become common due to an …

MicroRNAs (miRNAs) are a class of∼ 22 nt non-coding RNAs that control diverse biological
functions in animals, plants and unicellular eukaryotes by promoting degradation or …

Despite progress in mechanistic understanding of the RNA interference (RNAi) pathways,
the subcellular sites of RNA silencing remain under debate. Here we show that loading of …

Nearly every cell in the human body contains a set of programmable gene-silencing proteins
named Argonaute. Argonaute proteins mediate gene regulation by small RNAs and thereby …

Delivery of siRNA is a key hurdle to realizing the therapeutic promise of RNAi. By targeting
internalizing cell surface antigens, antibody–siRNA complexes provide a possible solution …

Abstract microRNAs are small, non-coding RNAs that influence diverse biological functions
through the repression of target genes during normal development and pathological …

P-bodies (processing bodies) are cytoplasmic foci visible by light microscopy in somatic
cells of vertebrate and invertebrate origin as well as in yeast, plants and trypanosomes. At …

MicroRNAs (miRNAs) are small, noncoding RNAs that influence diverse biological
outcomes through the repression of target genes during normal development and …

A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human
kinome was used to discover regulators of RNAi. Here we report that the proto-oncogene Akt …