Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that
contribute to the building of the heart leads to cardiac malformations, which frequently result …

During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the
cartilage, bone and connective tissue that make up the developing head. Although the initial …

Charles Darwin, while trying to devise a general theory of heredity from the observations of
animal and plant breeders, discovered that domesticated mammals possess a distinctive …

Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing
the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of …

Summary Background Del22q11. 2 syndrome is the most frequent known chromosomal
microdeletion syndrome, with an incidence of 1 in 4000–5000 livebirths. It is characterised …

The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-
dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that …

The thymus is the primary organ responsible for generating functional T cells in vertebrates.
Although T cell differentiation within the thymus has been an area of intense investigation …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

This review discusses the function of neural crest as they relate to cardiovascular defects.
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly …