E-cadherin in contact inhibition and cancer
AM Mendonsa, TY Na, BM Gumbiner - Oncogene, 2018 - nature.com
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion
and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells …
and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells …
The claudins: from tight junctions to biological systems
S Tsukita, H Tanaka, A Tamura - Trends in biochemical sciences, 2019 - cell.com
Claudins are cell–cell adhesion molecules located at the tight junctions (TJs) between cells
in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane …
in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane …
Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …
biological, and chemical signals to embraced cells. Increasing evidence suggests that …
Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification
To establish and maintain organ structure and function, tissues need to balance stem cell
proliferation and differentiation rates and coordinate cell fate with position. By quantifying …
proliferation and differentiation rates and coordinate cell fate with position. By quantifying …
The mechanobiology of tight junctions
S Citi - Biophysical reviews, 2019 - Springer
Tight junctions (TJ) play a central role in the homeostasis of epithelial and endothelial
tissues, by providing a semipermeable barrier to ions and solutes, by contributing to the …
tissues, by providing a semipermeable barrier to ions and solutes, by contributing to the …
Application of FRET biosensors in mechanobiology and mechanopharmacological screening
Extensive studies have shown that cells can sense and modulate the biomechanical
properties of the ECM within their resident microenvironment. Thus, targeting the …
properties of the ECM within their resident microenvironment. Thus, targeting the …
[HTML][HTML] Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium
Aging epithelia are colonized by somatic mutations, which are subjected to selection
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
Bioelectric signaling: role of bioelectricity in directional cell migration in wound healing
In wound healing, individual cells' behaviors coordinate movement toward the wound center
to restore small or large barrier defects. The migration of epithelial cells as a continuous …
to restore small or large barrier defects. The migration of epithelial cells as a continuous …
Adherens junctions and desmosomes coordinate mechanics and signaling to orchestrate tissue morphogenesis and function: an evolutionary perspective
M Rübsam, JA Broussard… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …
[HTML][HTML] Stretching the limits of extracellular signal-related kinase (ERK) signaling—cell mechanosensing to ERK activation
Extracellular signal-regulated kinase (ERK) has been recognized as a critical regulator in
various physiological and pathological processes. Extensive research has elucidated the …
various physiological and pathological processes. Extensive research has elucidated the …